Just thought I would tell you that I read an article recently about nebulized glutathione and how it is a remarkable treatment for COPD. I wish I could remember where I read it. I know you said your COPD doesn’t require medication or supplemental oxygen, but it may be something to keep in mind.
Please don't flood the thread. If you wish to supply links to the research, fine. But to cut and paste what AI says without references won't be tolerated. In fact the one link you supplied can be considered spam... 'realhealthmedical.com'
"glutathione can’t penetrate cellular lipid membranes—has merit and is rooted in its biochemical properties:"
Your long post has confirmed what I said,... and really adds nothing further to the discussion. I had mentioned it can have extracellular benefits. But so can its precursor, NAC, which can also be nebulized. So why would you want to handicap yourself and take something that is limited in its functional capacity?
Sorry, just trying to help. I watched my Dad and a beloved uncle experience an excruciating, drawn out death where every single breath was a tremendous struggle from COPD, just trying to put info out there to potentially save someone else from that awful fate.
That's ok. BTW, did you delete your post or did substack? I was willing to leave it up.
BTW, all those benefits with nebulized glutathione, are also seen with NAC,.. i.e... antioxidant, mucolytic effects, anti-inflammatory, etc...
COPD is not fun. I have seen it progress somewhat in ten years. But there are studies (2 that I have seen) where Quercetin has stop it in its tracks. And Quercetin has synergistic (enhancing) effects with NAC and vitamin C. Also NAC and vitamin C enhance one another. So all 3 together enhance each other. And I have easily seen the benefits.
My blood oxygen levels are still in the high 90's. Lower 90's when sleeping.
I deleted it. I understand your comments about NAC; however, it is my understanding that with age and illness, the body’s ability to efficiently produce Glutathione diminishes even with NAC supplementation.
A Midwestern Doctor on The Forgotten Side of Medicine Substack has an article if you’re interested.
The elderly and those with an illness are well known to be deplete in Glutathione. But when given NAC, stores are immediately recovered. This has been shown over and over. And happens routinely in ER's around the world, in the treatment of Tylenol overdose. Cysteine is the rate limiting amino acid in the production of this simple tripeptide. The other two amino acids are abundant in the food supply, so no need to supplement them.
Never have I heard, NAC was ineffective in the elderly. In fact, just the opposite has been shown in many studies.
A Midwestern Doctor is recommended at my home page. I plan on doing a substack using his research on shedding. But in his article on COPD, he makes no mention of nebulized glutathione's intracellular shortcomings. Nor any mention of NAC greatly enhancing glutathione stores.
So while supplemental Glutathione will have extracellular benefits, it anti-oxidant potential within a cell,.. will not be furnished to multicellular organelles. Including its important role in cell signaling. Which is why precursors such as NAC, whey protein, etc.. are preferred.
This is the big cavate concerning all Glutathione supplements. It won't fully protect cells. Most of its benefits happen within a cell.
I have read this long ago. If new research has emerged, I will gladly look at it. The whole redox homeostasis of Glutathione cannot be fully observed, so our knowledge remains remarkably limited. https://pubmed.ncbi.nlm.nih.gov/30427707/
Thank you for all the information you share to help others 🫶
Just thought I would tell you that I read an article recently about nebulized glutathione and how it is a remarkable treatment for COPD. I wish I could remember where I read it. I know you said your COPD doesn’t require medication or supplemental oxygen, but it may be something to keep in mind.
Thanks for the information!
Please don't flood the thread. If you wish to supply links to the research, fine. But to cut and paste what AI says without references won't be tolerated. In fact the one link you supplied can be considered spam... 'realhealthmedical.com'
"glutathione can’t penetrate cellular lipid membranes—has merit and is rooted in its biochemical properties:"
Your long post has confirmed what I said,... and really adds nothing further to the discussion. I had mentioned it can have extracellular benefits. But so can its precursor, NAC, which can also be nebulized. So why would you want to handicap yourself and take something that is limited in its functional capacity?
Sorry, just trying to help. I watched my Dad and a beloved uncle experience an excruciating, drawn out death where every single breath was a tremendous struggle from COPD, just trying to put info out there to potentially save someone else from that awful fate.
That's ok. BTW, did you delete your post or did substack? I was willing to leave it up.
BTW, all those benefits with nebulized glutathione, are also seen with NAC,.. i.e... antioxidant, mucolytic effects, anti-inflammatory, etc...
COPD is not fun. I have seen it progress somewhat in ten years. But there are studies (2 that I have seen) where Quercetin has stop it in its tracks. And Quercetin has synergistic (enhancing) effects with NAC and vitamin C. Also NAC and vitamin C enhance one another. So all 3 together enhance each other. And I have easily seen the benefits.
My blood oxygen levels are still in the high 90's. Lower 90's when sleeping.
I deleted it. I understand your comments about NAC; however, it is my understanding that with age and illness, the body’s ability to efficiently produce Glutathione diminishes even with NAC supplementation.
A Midwestern Doctor on The Forgotten Side of Medicine Substack has an article if you’re interested.
https://open.substack.com/pub/amidwesterndoctor/p/what-wildfire-illness-can-teach-us
Good luck with your wellness journey.
The elderly and those with an illness are well known to be deplete in Glutathione. But when given NAC, stores are immediately recovered. This has been shown over and over. And happens routinely in ER's around the world, in the treatment of Tylenol overdose. Cysteine is the rate limiting amino acid in the production of this simple tripeptide. The other two amino acids are abundant in the food supply, so no need to supplement them.
Never have I heard, NAC was ineffective in the elderly. In fact, just the opposite has been shown in many studies.
A Midwestern Doctor is recommended at my home page. I plan on doing a substack using his research on shedding. But in his article on COPD, he makes no mention of nebulized glutathione's intracellular shortcomings. Nor any mention of NAC greatly enhancing glutathione stores.
Thank you. That was very kind of you.
But here's the thing about Glutathione,... Its synthesis occurs inside cells. It can't penetrate/transverse the cellular lipid membrane...
"No evidence for any penetration of glutathione into the membrane was found." https://www.sciencedirect.com/science/article/pii/S0005273615002382
So while supplemental Glutathione will have extracellular benefits, it anti-oxidant potential within a cell,.. will not be furnished to multicellular organelles. Including its important role in cell signaling. Which is why precursors such as NAC, whey protein, etc.. are preferred.
This is the big cavate concerning all Glutathione supplements. It won't fully protect cells. Most of its benefits happen within a cell.
I have read this long ago. If new research has emerged, I will gladly look at it. The whole redox homeostasis of Glutathione cannot be fully observed, so our knowledge remains remarkably limited. https://pubmed.ncbi.nlm.nih.gov/30427707/